1,3-Propanediamine → HCID 178454313, compound

HRID 2258161Notes

Reaction equation

HRID 2258161 reaction equation
[C:1]([O:5][C:6]([N:8]=[C:9](C1C(C)=NNC=1C)[NH2:10])=[O:7])([CH3:4])([CH3:3])[CH3:2].[NH2:18][CH2:19][CH2:20][CH2:21][NH2:22]>>[NH2:18][CH2:19][CH2:20][CH2:21][NH:22][C:9]([NH:8][C:6]([O:5][C:1]([CH3:2])([CH3:3])[CH3:4])=[O:7])=[NH:10]

Participants

3

Reactant 2

HCID 4281,3-PropanediamineHCID 136003014HCID 136003014, compound

Product 1

HCID 178454313HCID 178454313, compoundYield 47%

Procedure

A mixture of tert-butoxycarbonyl-1-(3,5-dimethylpyrazolyl)-formamidine (0.38 g, 1.5 mmol) and 1,3-diaminopropane (0.56 g, 7.5 mmol) was stirred at room temperature for 17 h. The crystalline product was collected by filtration, washed with toluene (2×0.7) mL), and vacuum dried (35° C., 1.5 h) to afford 0.15 g (47%) of white crystals of N-(3-aminopropyl)-N'-tert-butoxycarbonyl guanidine (IIIg).

Workup

  1. filtrationThe crystalline product was collected by filtration
  2. washwashed with toluene (2×0.7) mL), and vacuum
  3. customdried (35° C., 1.5 h)

Sources & evidence

ORD record
ord-f943dd790f9b448c8998df2b833618fa
Source dataset
uspto-grants-1997_08
Patent number
US05659071

Reaction notes

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