Hydrochloric Acid → HCID 22865764, compound

Participants

Reaction Conditions

Reaction Steps

A 1.2M diisobutylal hydridesolution in toluene (4.2 ml) is slowly added dropwise at -75° C. to a solution of 2(S)-(tert-butoxycarbonyl)amino-4(S)-(p-tert-butyl-benzyl)-5-methyl-hexanoic acid ethyl ester (1 g) in toluene (20 ml). The reaction mixture is stirred for 30 minutes at -70° C., then 10 ml of methanol are added and the mixture is poured onto a mixture of ice and 1N hydrochloric acid (10 ml) and extracted with ethyl acetate. The title compound is obtained: Rf (dichloromethane)=0.35.

Provenance & Evidence