3-(Benzyloxy)pyridine-2-carboxylic acid → HCID 11857405, compound

HRID 2258310Notes

Reaction equation

HRID 2258310 reaction equation
[CH2:1]([O:8][C:9]1[C:10]([C:15]([OH:17])=O)=[N:11][CH:12]=[CH:13][CH:14]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(C1C=CC(C)=CC=1)(O)(=O)=O.[CH2:29]([O:37][C:38](=[O:41])[CH2:39][NH2:40])[CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH3:36]>>[CH2:29]([O:37][C:38]([CH2:39][NH:40][C:15]([C:10]1[C:9]([O:8][CH2:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)=[CH:14][CH:13]=[CH:12][N:11]=1)=[O:17])=[O:41])[CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH3:36]

Participants

3

Reactant 2

HCID 153381863-(Benzyloxy)pyridine-2-carboxylic acidHCID 19428418HCID 19428418, compound

Product 1

HCID 11857405HCID 11857405, compound

Procedure

1.1 g (5 mmol) of 3-benzyloxypyridine-2-carboxylic acid were condensed with glycine 1-octyl ester tosylate in analogy with Example 147. 1.3 g of the title compound were obtained, without column chromatography, as a pale brown oil, 1H NMR (DMSO): δ=5.24 (s, CH2 -benzyl).

Sources & evidence

ORD record
ord-25291aa5fd454592ba757bf4634e5f54
Source dataset
uspto-grants-1997_08
Patent number
US05658933

Reaction notes

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