Water → HCID 22923792, compound

Participants

Reaction Conditions

Reaction Steps

4.6 g (12 mmol) of dibenzyl 3-chloropyridine-2,5-dicarboxylate were dissolved, at 20° C. and while stirring, in 30 ml of dimethyl sulfoxide, and after that 5.0 g (70 mmol) of sodium thiomethoxide were added, in association with which the temperature rose to 80° C. The reaction mixture was heated at 140° C. for 1 h and then cooled down, after which water was added to it; the oily layer was separated off and cone. hydrochloric acid (pH 1) was added to the aqueous DMSO phase, and the precipitated product was filtered off with suction. 2.8 g of yellow crystalline product were obtained, m.p. 223° C. (with decomposition).

Provenance & Evidence