(3S)-pyrrolidin-3-ol → (3S)-3-Hydroxy-N-(6-methoxypyridin-3-yl)pyrrolidine-1-carbothioamide

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Reaction Steps

The title compound was prepared from (S)-3-hydroxypyrrolidine and 5-isothiocyanato-2-methoxypyridine (J. Org. Chem. (1980), 45, 4219), using the same method as that described for preparation 35, in 99% yield. 1H NMR(400 MHz, CD3OD) δ: 1.91-2.22(m, 2H), 3.69-3.81(m, 4H), 3.88(s, 3H), 4.40-4.52(m, 1H), 6.78(d, 1H), 7.69(dd, 1H), 8.00(m, 1H); LCMS m/z 254 [M+H]+

Provenance & Evidence