HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → Z-Gly-Gly-OtBu
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Benzyloxycarbonylglycine | HCID 14349 | — |
| Reactant | Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate | HCID 151348 | — |
| Reactant | Glycine tert-butyl ester | HCID 151417 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | Z-Gly-Gly-OtBu | HCID 15403804 | 79% |
Reaction Steps
N-Carbobenzyloxy-glycine (2.1 g, 10 mmol) and glycine-tert-butyl ester (1.3 g, 10 mmol) were coupled using benzotriazol-1-yloxytris(dimethylamino) phosphonium hexafluorophosphate (4.4 g, 10 mmol) and triethylamine (1.5 g, 15 mmol) in acetonitrile following the method described in Example 23 to give 2.5 g(79%) of N-carbobenzyloxy-glycylglycine-tert-butyl ester after chromatography on silica gel.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05658908 |
| Source dataset | uspto-grants-1997_08 |
| ORD ID | ord-4c06431601584ab6b5d606d982c995da |
| Source note | uspto-grants-1997_08 |