Imidazole → HCID 604423, compound

HRID 2258327Notes

Reaction equation

HRID 2258327 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[OH:9].[C:10]([Si:14](Cl)([CH3:16])[CH3:15])([CH3:13])([CH3:12])[CH3:11].N1C=CN=C1>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[C:3]=1[O:9][Si:14]([C:10]([CH3:13])([CH3:12])[CH3:11])([CH3:16])[CH3:15]

Participants

4

Reactant 3

HCID 795ImidazoleHCID 28928tert-Butyldimethylsilyl chlorideHCID 943922,6-Difluorophenol

Product 1

HCID 604423HCID 604423, compoundYield 83.2%

Procedure

2,6-Difluorophenol (8.6 g, 66 mmol) was treated with tert -butylchlorodimethylsilane (17.4 g, 0.12 mol) and imidazole (13.1 g, 0.19 mol) by the method in Example 1 to give 13.41 g (83%) of tert-butyldimethylsilyl 2,6-difluorophenyl ether.

Sources & evidence

ORD record
ord-567e96d33ff341289af683873e86d07f
Source dataset
uspto-grants-1997_08
Patent number
US05658908

Reaction notes

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