HuagongsheHuagongshe Chemistry Print Report · For research reference only
N,N-diethyl-4-formylbenzamide → HCID 54349341, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N,N-diethyl-4-formylbenzamide | HCID 10954698 | — |
| Reactant | 1-(3-Bromophenyl)-2,2,5,5-tetramethyl-1-aza-2,5-disilacyclopentane | HCID 13268665 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Product | HCID 54349341 | HCID 54349341 | 25.2% |
Reaction Steps
The protected aniline (23.64 g, 0.101 mol) was treated with n-butyllithium (1.5M in hexane, 66 mL, 0.101 mol) and 4-formyl-N,N -diethylbenzamide (20.70 g, 0.101 mol) as in Example11. Chromatography of the crude product on silica gel (Waters Prep 500, dichloromethane:ethanol/100:1-3) gave 7.59 g (25%) of 4-(3-amino-α-hydroxybenzyl)-N,N-diethylbenzamide as a light yellow hygroscopic solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05658908 |
| Source dataset | uspto-grants-1997_08 |
| ORD ID | ord-e7c072720f5540d3bf6f40c64ff69515 |
| Source note | uspto-grants-1997_08 |