HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromoacetic Acid → 18-[[3-(2-Carboxybutyl)-2,4,6-triiodophenyl]amino]-3,6,9-tris(carboxymethyl)-11,18-dioxo-3,6,9,12-tetraazaoctadecanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromoacetic Acid | HCID 6227 | — |
| Reactant | 3-[6-[[[2-[(2-Aminoethyl)amino]ethyl]amino]acetyl amino]-1-oxohexyl]amino-alpha-ethyl-2,4,6-triiodobenzenepropanoic acid | HCID 22921396 | — |
| Solvent | Water | HCID 962 | — |
| Product | 18-[[3-(2-Carboxybutyl)-2,4,6-triiodophenyl]amino]-3,6,9-tris(carboxymethyl)-11,18-dioxo-3,6,9,12-tetraazaoctadecanoic acid | HCID 10419126 | 41.3% |
Reaction Steps
According to the procedure described in Example 1, 52.1 g of bromoacetic acid (0.375 mol) are reacted with 62 g of compound (B) 3-[6- [[[2-[(aminoethyl)amino]ethyl]amino]acetylamino]-1-oxohexyl]amino-α-ethyl-2,4,6-triiodobenzenepropanoic acid (0.075 mol) in 400 ml of H2O. 32.9 g of 18-[[3-(2-carboxybutyl)-2,4,6-triiodophenyl]amino]-3,6,9-tris(carboxymethyl)-11,18-dioxo-3,6,9,12-tetraazaoctadecanoic acid (0.031 mol) are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05660814 |
| Source dataset | uspto-grants-1997_08 |
| ORD ID | ord-12e3ee97c06b45208740793005b25f61 |
| Source note | uspto-grants-1997_08 |