HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromoacetic Acid → 10-[2-[[3-(2-Carboxybutyl)-2,4,6-triiodophenyl]amino]-2-oxoethyl]-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromoacetic Acid | HCID 6227 | — |
| Reactant | N-[3-(2-carboxybutyl)-2,4,6-triiodophenyl]-1,4,7,10-tetraazacyclododecane-1-acetamide | HCID 22921399 | — |
| Reactant | N-(3-carboxy-2,4,6-triiodophenyl)-1,4,7,10-tetraazacyclododecane-1-acetamide | HCID 22921403 | — |
| Solvent | Water | HCID 962 | — |
| Product | 10-[2-[[3-(2-Carboxybutyl)-2,4,6-triiodophenyl]amino]-2-oxoethyl]-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid | HCID 10677949 | 13.4% |
Reaction Steps
According to the procedure described in Example 3, 17.74 g of bromoacetic acid (0.127 mol) in 20 ml of H2O are reacted with 25 g of compound (B) N-[3-(2-carboxybutyl)-2,4,6-triiodophenyl]-1,4,7,10-tetraazacyclododecane-1-acetamide (0.032 mol) in 20 ml of H2O. 4.1 g of 10-[2-[[3-(2-carboxybutyl)-2,4,6-triiodophenyl]amino]-2-oxoethyl ] -1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid (0.0043 mol) are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05660814 |
| Source dataset | uspto-grants-1997_08 |
| ORD ID | ord-7908b8e73bc143ccb30229fadcbb398a |
| Source note | uspto-grants-1997_08 |