Ammonium Hydroxide → 3-[(2-Aminoacetyl)amino]-2,4,6-triiodobenzoic acid

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Reaction Steps

6.34 g of 3-[(2-chloroacetyl)amino]-2,4,6-triiodobenzoic acid (prepared as described in Example 3) (10.72 mmol) are dissolved in 250 ml of 25% NH4OH and the solution is kept in autoclave for 35 hours at r.t. The mixture is evaporated to dryness and the residue is then dissolved in H2O, adjusting the pH to 7 and yielding a precipitate, which is filtered. 5.74 g of 3-[(2-aminoacetyl)amino]-2,4,6-triiodobenzoic acid (10.04 mmol) are obtained.

Provenance & Evidence