HCID 22921473, compound → HCID 22921474, compound

Participants

Reaction Steps

A 3-necked round-bottomed flask was charged with methyl 4-cyano-4-(4-nitrophenyl)hexanoate (20.0 g), 90% ethanol (1000 ml) and PtO2 (1.0 g). The vessel was then evacuated and charged with nitrogen. The mixture was stirred vigorously and subjected to H2 at atmospheric pressure supplied via a balloon. The catalyst was removed by filtration through celite and the solvent removed under reduced pressure to give methyl 4-cyano-4-(4-aminophenyl)-hexanoate (18 g, 100%) as a viscous, brown oil.

Provenance & Evidence