Nitric Acid → HCID 18968198, compound
Reaction equation
[N+:1]([O-:4])(O)=[O:2].OS(O)(=O)=O.[C:10]1([CH:16]([CH2:19][CH3:20])[C:17]#[N:18])[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>>[N+:1]([C:13]1[CH:14]=[CH:15][C:10]([CH:16]([CH2:19][CH3:20])[C:17]#[N:18])=[CH:11][CH:12]=1)([O-:4])=[O:2]Participants
Conditions
- Temperature
- 10 °C
Procedure
A 3-necked round-bottomed flask was charged with conc. HNO3 (240 ml) and cooled to 10° C. with the aid of an ice/acetone bath. Conc. H2SO4 (240 ml) was then added slowly so as to maintain the temperature below 30° C. 2-Phenylbutyronitrile (Aldrich, 110 ml) was introduced dropwise to the stirred solution over a period of 1 hour, maintaining the temperature below 20° C. The ice/acetone bath was then removed and the mixture stirred for a further 30 minutes at ambient temperature before pouring it onto crushed ice (100 g). The resulting mixture was extracted with ethyl acetate (1500 ml×2) and the extracts pooled, washed with saturated bicarb. (1000 ml) and water (500 ml). After drying over MgSO, the ethyl acetate was evaporated under reduced pressure to give crude 2-(4-nitrophenyl)butyronitrile as a yellow oil, crude yield 138 g, 98%. Analysis by GC.MS indicated a para:meta ratio of 3.5:1.
Workup
- temperatureto maintain the temperature below 30° C
- temperaturemaintaining the temperature below 20° C
- customThe ice/acetone bath was then removed
- additionbefore pouring it
- customonto crushed ice (100 g)
- extractionThe resulting mixture was extracted with ethyl acetate (1500 ml×2)
- washwashed with saturated bicarb
- dry with materialAfter drying over MgSO
- customthe ethyl acetate was evaporated under reduced pressure
Sources & evidence
- ORD record
- ord-7ffad6f60e1c43ea93f12e1d6c7742ac
- Source dataset
- uspto-grants-1997_08
- Patent number
- US05661014
Reaction notes
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