Water → HCID 135430303, compound

HRID 2258430Notes

Reaction equation

HRID 2258430 reaction equation
[CH2:1]([NH2:3])[CH3:2].Cl[C:5]1[CH:14]=[C:13]2[C:8]([C:9](=[O:15])[NH:10][CH:11]=[N:12]2)=[CH:7][C:6]=1[N+:16]([O-:18])=[O:17].O>C(O)C>[CH2:1]([NH:3][C:5]1[CH:14]=[C:13]2[C:8]([C:9](=[O:15])[NH:10][CH:11]=[N:12]2)=[CH:7][C:6]=1[N+:16]([O-:18])=[O:17])[CH3:2]

Participants

5

Reactant 3

HCID 962WaterHCID 6341EthylamineHCID 1356875047-Chloro-6-nitroquinazolin-4(1H)-one

Product 1

HCID 135430303HCID 135430303, compoundYield 39%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
110 °C

Procedure

A 70% aqueous ethylamine solution (40 ml) was added to a solution (70 ml) of 7-chloro-6-nitro-4(3H)-quinazolone (6.31 g, 28.4 mmol) in ethanol and the mixture was heated with stirring at 110° C. for 4 hours in a sealed tube. After cooling to room temperature, the reaction mixture was poured into water and the precipitated crystals were filtered off. The crystals were washed with ethanol and dried to give the title compound (2.6 g, 39%).

Workup

  1. temperaturethe mixture was heated
  2. temperatureAfter cooling to room temperature
  3. filtrationthe precipitated crystals were filtered off
  4. washThe crystals were washed with ethanol
  5. customdried

Sources & evidence

ORD record
ord-b87f7b444c444c90bfa99775001fcac2
Source dataset
uspto-grants-1997_08
Patent number
US05661147

Reaction notes

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