HuagongsheHuagongshe Chemistry Print Report · For research reference only
Urea → Urea, 1-(p-fluorophenyl)-3-methyl-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Urea | HCID 1176 | — |
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | Cyanoacetic acid | HCID 9740 | — |
| Reactant | 4-Fluorophenyl isocyanate | HCID 70955 | — |
| Reactant | HCID 15859067 | HCID 15859067 | — |
| Reactant | 6-Amino-1-(4-fluorophenyl)-3-methylpyrimidine-2,4(1H,3H)-dione | HCID 22922003 | — |
| Reactant | Sodium Nitrite | HCID 23668193 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Product | Urea, 1-(p-fluorophenyl)-3-methyl- | HCID 96348 | — |
Reaction Steps
N-Methyl-N'-(4-fluorophenyl)urea was prepared preliminarily from 4-fluorophenyl isocyanate and methylamine by the same procedure as in Reference Example 1. The urea compound as the starting material was reacted with cyanoacetic acid to form a uracil ring. Using sodium nitrite a nitroso group was introduced into the 5-position of the uracil ring in the obtained 6-amino-3-methyl-1-(4-fluorophenyl)uracil and then reduced with hydrogen gas to prepare 5,6-diamino-1-(4-fluorophenyl)-3-methyluracil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05661153 |
| Source dataset | uspto-grants-1997_08 |
| ORD ID | ord-b22e92406c9345efb16440fa9f2eabb2 |
| Source note | uspto-grants-1997_08 |