HuagongsheHuagongshe Chemistry Print Report · For research reference only
Urea → Urea, N-phenyl-N'-propyl-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Urea | HCID 1176 | — |
| Reactant | Phenyl isocyanate | HCID 7672 | — |
| Reactant | Propylamine | HCID 7852 | — |
| Reactant | Cyanoacetic acid | HCID 9740 | — |
| Reactant | 5,6-Diamino-1-phenyl-3-propylpyrimidine-2,4(1H,3H)-dione | HCID 15859068 | — |
| Reactant | 6-Amino-1-phenyl-3-propylpyrimidine-2,4(1H,3H)-dione | HCID 22922091 | — |
| Reactant | Sodium Nitrite | HCID 23668193 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Product | Urea, N-phenyl-N'-propyl- | HCID 3604138 | — |
Reaction Steps
N-Propyl-N'-phenylurea was prepared preliminarily from phenyl isocyanate and propylamine by the same procedure as in Reference Example 1. The urea compound as the starting material was reacted with cyanoacetic acid to form a uracil ring. Using sodium nitrite a nitroso group was introduced into the 5-position of the uracil ring in the obtained 6-amino-1-phenyl-3-propyluracil and then reduced with hydrogen gas to prepare 5,6-diamino-1-phenyl-3-propyluracil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05661153 |
| Source dataset | uspto-grants-1997_08 |
| ORD ID | ord-63a3d71f38ba47f682fe485b3b780e32 |
| Source note | uspto-grants-1997_08 |