HuagongsheHuagongshe Chemistry Print Report · For research reference only
Urea → 1-(2-Chlorophenyl)-3-methylurea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Urea | HCID 1176 | — |
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | Cyanoacetic acid | HCID 9740 | — |
| Reactant | Chlorophenyl isocyanate | HCID 76833 | — |
| Reactant | HCID 22922058 | HCID 22922058 | — |
| Reactant | HCID 22922081 | HCID 22922081 | — |
| Reactant | Sodium Nitrite | HCID 23668193 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Product | 1-(2-Chlorophenyl)-3-methylurea | HCID 139946 | — |
Reaction Steps
N-Methyl-N'-(2-chlorophenyl)urea was prepared preliminarily from 2-chlorophenyl isocyanate and methylamine by the same procedure as in Reference Example 1. The urea compound as the starting material was reacted with cyanoacetic acid to form a uracil ring. Using sodium nitrite a nitroso group was introduced into the 5-position of the uracil ring in the obtained 6-amino-1-(2-chlorophenyl)-3-methyluracil and then reduced with hydrogen gas to prepare 1-(2-chlorophenyl)-5,6-diamino-3-methyluracil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05661153 |
| Source dataset | uspto-grants-1997_08 |
| ORD ID | ord-15c6fd0fdb604cbdbd8a09031720ab08 |
| Source note | uspto-grants-1997_08 |