HuagongsheHuagongshe Chemistry Print Report · For research reference only
Urea → N-(3-chlorophenyl)-N'-methylurea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Urea | HCID 1176 | — |
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | Cyanoacetic acid | HCID 9740 | — |
| Reactant | Benzene, 1-chloro-3-isocyanato- | HCID 17968 | — |
| Reactant | HCID 1649260 | HCID 1649260 | — |
| Reactant | HCID 22922001 | HCID 22922001 | — |
| Reactant | Sodium Nitrite | HCID 23668193 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Product | N-(3-chlorophenyl)-N'-methylurea | HCID 30384 | — |
Reaction Steps
N-Methyl-N'-(3-chlorophenyl)urea was prepared preliminarily from 3-chlorophenyl isocyanate and methylamine by the same procedure as in Reference Example 1. The urea compound as the starting material was reacted with cyanoacetic acid to form a uracil ring. Using sodium nitrite a nitroso group was introduced into the 5-position of the uracil ring in the obtained 6-amino-1-(3-chlorophenyl)-3-methyluracil and then reduced with hydrogen gas to prepare 1-(3-chlorophenyl)-5,6-diamino-3-methyluracil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05661153 |
| Source dataset | uspto-grants-1997_08 |
| ORD ID | ord-933a010268e9401ab672f841eba005ef |
| Source note | uspto-grants-1997_08 |