HuagongsheHuagongshe Chemistry Print Report · For research reference only
Urea → N-methyl-N'-(1-naphthyl)urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Urea | HCID 1176 | — |
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | Cyanoacetic acid | HCID 9740 | — |
| Reactant | alpha-Naphthyl isocyanate | HCID 66589 | — |
| Reactant | HCID 1649267 | HCID 1649267 | — |
| Reactant | HCID 22922103 | HCID 22922103 | — |
| Reactant | Sodium Nitrite | HCID 23668193 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Product | N-methyl-N'-(1-naphthyl)urea | HCID 308345 | — |
Reaction Steps
N-Methyl-N'-(1-naphthyl)urea was prepared preliminarily from 1-naphthyl isocyanate and methylamine by the same procedure as in Reference Example 1. The urea compound as the starting material was reacted with cyanoacetic acid to form a uracil ring. Using sodium nitrite a nitroso group was introduced into the 5-position of the uracil ring in the obtained 6-amino-3-methyl-1-(1-naphthyl)uracil and then reduced with hydrogen gas to prepare 5,6-diamino-3-methyl-1-(1-naphthyl)uracil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05661153 |
| Source dataset | uspto-grants-1997_08 |
| ORD ID | ord-4d2c159ee4514193b7e92e70a67f8a43 |
| Source note | uspto-grants-1997_08 |