1,8-Diazabicyclo(5.4.0)undec-7-ene → Methyl 5-acetylbenzofuran-2-carboxylate

HRID 2258506ノート

反応式

HRID 2258506 の反応式
[C:1]([C:4]1[CH:5]=[CH:6][C:7]([O:12][CH2:13][C:14]([O:16][CH3:17])=[O:15])=[C:8]([CH:11]=1)[CH:9]=O)(=[O:3])[CH3:2].C1CCN2C(=NCCC2)CC1>C1(C)C=CC=CC=1>[C:1]([C:4]1[CH:5]=[CH:6][C:7]2[O:12][C:13]([C:14]([O:16][CH3:17])=[O:15])=[CH:9][C:8]=2[CH:11]=1)(=[O:3])[CH3:2]

参加物

4

反応物 2

HCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 229222125-Acetyl-2-(methoxycarbonyl) methoxybenzaldehyde

生成物 1

HCID 18918314Methyl 5-acetylbenzofuran-2-carboxylate収率 40%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒2 回

実験手順

To a mixture of 5-acetyl-2-(methoxycarbonyl) methoxybenzaldehyde (4.47 g) in toluene, a solution of 1,8-diazabicyclo[5.4.0]-7-undecene (1.30 g) in toluene (8 ml) was added dropwise for 15 hours at refluxing temperature. After being cooled, the resulting mixture was washed with water, dried lover magnesium sulfate and concentrated under reduced pressure. The resulting precipitates were washed with diethyl ether to give 5-acetyl-2-methoxycarbonylbenzofuran (1.65 g).

後処理

  1. temperatureat refluxing temperature
  2. temperatureAfter being cooled
  3. washthe resulting mixture was washed with water
  4. dry with materialdried lover magnesium sulfate
  5. concentrationconcentrated under reduced pressure
  6. customThe resulting precipitates
  7. washwere washed with diethyl ether

出典と根拠

ORDレコード
ord-0e08e7fee9114594bb5ac0e2ece580a9
出典データセット
uspto-grants-1997_08
特許番号
US05661159

反応ノート

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