反应详情

A mixture of 7-chloro-2-(5-Chloromethylbenzofuran-2-yl)quinoline (0.45 g), methyl 2-mercaptopropionate (0.27 g), potassium carbonate (1.7 g) and Aliquat 336 (phase transfer 0.1 g) in a mixture of toluene (60 ml) and water (5 ml) was stirred at ambient temperature for 2 days. The organic layer was separated, washed with brine, dried over magnesium sulfate and concentrated in reduced pressure. The resulting residue was subjected to column chromatography on silica gel and eluted with a mixture of ethyl acetate and toluene (1:10). The fractions containing object Compound were combined and concentrated under reduced pressure to give 7-chloro-2-[5-[2-(methoxycarbonyl)ethylthiomethyl]benzofuran-2-yl]quinoline (0.38 g).

1. customThe organic layer was separated
2. washwashed with brine
3. dry with materialdried over magnesium sulfate
4. concentrationconcentrated in reduced pressure
5. washeluted with a mixture of ethyl acetate and toluene (1:10)
6. additionThe fractions containing object Compound
7. concentrationconcentrated under reduced pressure