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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2258525Generated: November 1, 2026

Methyl iodide → HCID 22922151, compound

https://huagongshe.com/reaction/2258525

Reaction equation

Participants

RoleNameHCIDCharge
ReactantMethyl iodideHCID 6328—
ReactantPotassium CarbonateHCID 11430—
ReactantHCID 136058237HCID 136058237—
SolventDimethylformamideHCID 6228—
SolventTetrahydrofuranHCID 8028—
ProductHCID 22922151HCID 2292215149.1%

Reaction Steps

A mixture of 7-chloro-2-(5-methoxycarbonyl-3-hydroxybenzofuran-2-yl)quinoline (1.0 g), potassium carbonate (0.39 g), and methyl iodide (0.40 g) in a mixture of tetrahydrofuran (20 ml) and N,N-dimethylformamide (8 ml) was stirred under reflux. After being cooled, the appeared precipitates were collected by filtration and washed with acetone to give 7-chloro-2-(5-methoxycarbonyl-3-methoxybenzofuran-2-yl)quinoline (0.51 g).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05661159
Source datasetuspto-grants-1997_08
ORD IDord-090213dfaa62473ea318ed1268dbcfc4
Source noteuspto-grants-1997_08