Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Butanamine, 2-methyl- → HCID 22922542, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Butanamine, 2-methyl- | HCID 68986 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate | HCID 151348 | — |
| 반응물 | 1-[4-(N-tert-Butylcarbamoyl)-2-methoxybenzyl]-3-cyclohexyl-5-ethoxy-1,3-dihydro-2H-benzimidazol-2-one | HCID 22922491 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | HCID 22922542 | HCID 22922542 | 36.7% |
반응 단계
To a solution of 0.9 g of the compound obtained in Example 15 Step B, 0.9 g of BOP and 1 ml of DIPEA in 20 ml of DCM is added 1 g of tert-amylamine, and the mixture is left stirring for 3 hours at RT. The reaction mixture is washed with 1N HCl solution, with 1N NaOH solution and dried over Na2SO4, and the solvent is evaporated off under vacuum. The residue is chromatographed on silica, eluting with DCM. 0.34 g of the expected product is obtained, mp=164° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05661169 |
| 출처 데이터셋 | uspto-grants-1997_08 |
| ORD ID | ord-f55ae4b4c20a4304814809370b70318a |
| 출처 메모 | uspto-grants-1997_08 |