反应详情

To a solution of 2-amino-3-(hydroxymethyl)pyridine (13.0 g, 116.0 mmole) in CH2Cl2 (300 mL) at RT was added NBS (22.71 g, 127.6 mmole). After stirring at RT for 45 min the reaction solution was concentrated and the residue was dissolved in CHCl3. The resulting suspension was filtered and the filtrate was concentrated to a dark oil. Purification on silica gel (EtOAc) afforded the title compound (78%, 18.36 g) as a tan solid: MS (ES) m/e 204 (M+H)+.

1. concentrationwas concentrated
2. dissolutionthe residue was dissolved in CHCl3
3. filtrationThe resulting suspension was filtered
4. concentrationthe filtrate was concentrated to a dark oil
5. customPurification on silica gel (EtOAc)