4-Toluenesulfonyl chloride → HCID 54385761, compound

Participants

Reaction Steps

Methyl-2-deoxy-D-ribose (8 g, 54 mmol) was dissolved in pyridine (60 mL). To this solution was added tosylchloride (10.86 g, 57 mmol) over 1 hour at 0° C. After 14 hours at room temperature, the solution was concentrated, quenched with ice water (250 mL), and extracted with ethyl acetate. The extract was washed with saturated NaHCO3, water, dried, filtered, and concentrated. The residue (13.6 g, 83.5% yield) was used directly. NMR

Provenance & Evidence