Trifluoroacetic acid → HCID 22921543, compound

Participants

Reaction Steps

In yet another example, when 2-(2-methylpropylamino)-4-(ethoxycarbonylamino)aniline (R is 2-methylpropyl, X is hydrogen) (13) was treated with trifluoroacetic acid in toluene as described above (Step D of Example 7), a 1:1 mixture of the intermediate 1-(2-methylpropyl)-2-trifluoromethyl-6-ethoxycarbonylaminobenzimidazole (6), and the uncyclized intermediate, N-trifluoromethylcarbonyl-2-[(trifluoromethylcarbonyl)(2-methylpropyl)amino]-4-(ethoxycarbonylamino)aniline (14) was obtained. Treatment of the mixture of the intermediate benzimidazole (6) and (14) with potassium carbonate and water in methanol resulted in the direct conversion of intermediate (14) to the intermediate benzimidazole (6).

Provenance & Evidence