Hydrochloric Acid → HCID 22921571, compound

Participants

Reaction Steps

A solution of 3.7 grams (0.007 mole) of N-trifluoromethylcarbonyl-2-[(trifluoromethylcarbonyl)(3-chlorophenylmethyl)amino]-4-ethoxycarbonylamino-5-fluoroaniline in 50 mL of methanol was stirred, and a solution of 1.0 gram (0.007 mole) of potassium carbonate in a minimum amount of water was added. The reaction mixture was then heated at reflux for about three hours, after which the reaction mixture was cooled, poured into cold water, and acidified to a pH of 6 with aqueous 3N hydrochloric acid. The resultant solid was collected by filtration and dried, yielding 3.2 grams of 2-[(trifluoromethylcarbonyl)(3-chlorophenylmethyl)amino]-4-ethoxycarbonylamino-5-fluoroaniline. The NMR spectrum was consistent with the proposed structure.

Provenance & Evidence