HCID 22921571, compound → HCID 22921563, compound

Participants

Reaction Steps

A stirred solution of 3.2 grams (0.007 mole) of 2-[(trifluoromethylcarbonyl)(3-chlorophenylmethyl)amino]-4-ethoxycarbonylamino-5-fluoroaniline in 100 mL of toluene was heated at reflux for about 4.5 hours. After this time, the reaction mixture was concentrated under reduced pressure to a residue, which was triturated with petroleum ether, and the resultant solid was collected by filtration, yielding 2.5 grams of 1-(3-chlorophenylmethyl)-2-trifluoromethyl-5-fluoro-6-ethoxycarbonylaminobenzimidazole, mp 144°-146° C. The NMR spectrum was consistent with the proposed structure.

Provenance & Evidence