Potassium Carbonate → HCID 22921578, compound

Participants

Reaction Steps

A solution of 1.3 grams (0.003 mole) of 3-[1-(2-methylpropyl)-2-trifluoromethyl-5-fluorobenzimidazol-6-yl]-6-trifluoromethyluracil (prepared as in Example 2, Steps A-H) in 30 mL of tetrahydrofuran is stirred, and 0.5 gram (0.003 mole) of potassium carbonate, then 0.7 gram (0.003 mole) of 1-aminooxysulfonyl-2,4,6-trimethylbenzene are added. Upon completion of the addition, the reaction mixture is stirred for one hour. The reaction mixture is then diluted with water and extracted with three portions of ethyl acetate. The combined extracts are dried with magnesium sulfate and filtered. The filtrate is concentrated under reduced pressure to a residue, which is purified by column chromatography, yielding 1-amino-3-[1-(2-methylpropyl)-2-trifluoromethyl-5-fluorobenzimidazol-6-yl]-6-trifluoromethyluracil.

Provenance & Evidence