Ethyl indole-2-carboxylate → Ethyl 5-fluoro-1-methyl-1H-indole-2-carboxylate

HRID 225866Notes

Reaction equation

HRID 225866 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:5]2.[CH2:16](OC(C1NC2C(C=1)=CC=CC=2)=O)C>>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH3:16])[C:6]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[CH:5]2

Participants

3

Reactant 2

HCID 73125Ethyl indole-2-carboxylateHCID 2727899ethyl 5-fluoro-1H-indole-2-carboxylate

Product 1

HCID 10775338Ethyl 5-fluoro-1-methyl-1H-indole-2-carboxylateYield 100%

Procedure

According to the procedure of Preparation 1(a), except substituting ethyl 5-fluoro-indole-2-carboxylate for the ethyl-indole-2-carboxylate, the title compound (3.3 g, 100%) was prepared as a white solid: MS (ES) m/e 222 (M+H)+.

Sources & evidence

ORD record
ord-75e4d2a916194fbe91543d177cd1bc48
Source dataset
uspto-grants-2009_07
Patent number
US07557125B2

Reaction notes

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