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HRID 2258763作成日：2026年10月25日

4-Phenylpiperidine-4-carboxamide monohydrochloride → 1-[2-[3-(3,4-Dichloro-phenyl)-1-(3,4,5-trimethoxy-benzyl)-pyrrolidin-3-yl]-ethyl]-4-phenyl-piperidine-4-carboxylic acid amide

https://huagongshe.com/reaction/2258763

反応式

関与物質

役割名称HCID仕込み量
反応物4-Phenylpiperidine-4-carboxamide monohydrochlorideHCID 3017129—
反応物2-[3-(3,4-Dichloro-phenyl)-1-(3,4,5-trimethoxy-benzyl)-pyrrolidin-3-yl]-ethyl-bromideHCID 53709262—
生成物1-[2-[3-(3,4-Dichloro-phenyl)-1-(3,4,5-trimethoxy-benzyl)-pyrrolidin-3-yl]-ethyl]-4-phenyl-piperidine-4-carboxylic acid amideHCID 53969650—

反応手順

Prepare according to the method of example 57.8 using 2-[3-(3,4-dichloro-phenyl)-1-(3,4,5-trimethoxy-benzyl)-pyrrolidin-3-yl]-ethyl-bromide (5 mmol) and 4-phenyl-piperidine-4-carboxylic acid amide hydrochloride (7.5 mmol, 1.5 eq.). Chromatograph on silica gel to give the title compound.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US05661160
出典データセットuspto-grants-1997_08
ORD IDord-a56760b756d5462cbbdbadc5176186c2
出典メモuspto-grants-1997_08