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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2258882Generated: November 2, 2026

6-Bromoquinoline → [5-Methyl-1-(oxan-2-yl)-1H-indazol-4-yl]boronic acid

https://huagongshe.com/reaction/2258882

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-BromoquinolineHCID 79243—
Reactant[5-Methyl-1-(oxan-2-yl)-1H-indazol-4-yl]boronic acidHCID 129009568—
ReagentSodium BicarbonateHCID 516892—
CatalystTris(1,1-dimethylethyl)phosphineHCID 83681—
Catalystpalladium(II) acetateHCID 167845—
SolventAcetonitrileHCID 6342—
ProductQuinolineHCID 70475.867%
Product6-BromoquinolineHCID 792435.429%
Product6,6'-BiquinolineHCID 62071110.234%
ProductHCID 10751213HCID 107512134.364%
Product[5-Methyl-1-(oxan-2-yl)-1H-indazol-4-yl]boronic acidHCID 12900956851.8%
ProductHCID 178422846HCID 17842284622.306%

Reaction Conditions

Temperature100 °C

Provenance & Evidence

DOI10.1021/jacs.2c08592
Source datasetHTE Suzuki coupling dataset
ORD IDord-3b1f7ed2706042458654107b4b1a3cfb
Source noteHTE Suzuki coupling dataset