Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → 3-[N-(benzyloxycarbonyl)-N-methylaminomethyl]-1H-indole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Benzyl succinimido carbonate | HCID 83172 | — |
| 반응물 | N-Methyl-1H-indole-3-methanamine | HCID 96388 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 3-[N-(benzyloxycarbonyl)-N-methylaminomethyl]-1H-indole | HCID 22139086 | 74% |
반응 단계
N-(Benzyloxycarbonyloxy)succinimide (8.9 g, 35.7 mmole) was added to a solution of 3-(methylaminomethyl)-1H-indole (5.2 g, 32.5 mmole) and triethylamine (5.0 mL. 65.7 mmole) in DMF (100 mL) at RT. The reaction was stirred overnight then was concentrated in vacuo. The residue was diluted with water and the mixture was extracted with ethyl acetate. The combined extracts were dried over Na2SO4 and concentrated. Flash chromatography on silica gel (33% ethyl acetate/hexanes) gave the title compound (7.0 g, 74%) as an off-white solid: MS (ES) m/e 295 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07557125B2 |
| 출처 데이터셋 | uspto-grants-2009_07 |
| ORD ID | ord-9475198559fe4beeadea91635219cce2 |
| 출처 메모 | uspto-grants-2009_07 |