HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → [(1,2-dimethyl-1H-indol-3-yl)methyl](methyl)amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Methylamine | HCID 6329 | — |
| Reactant | 1,2-Dimethyl-1H-indole-3-carboxaldehyde | HCID 599084 | — |
| Product | [(1,2-dimethyl-1H-indol-3-yl)methyl](methyl)amine | HCID 10877907 | — |
Reaction Steps
To 1,2-dimethylindole-3-carboxaldehyde (11.50 g, 66.4 mmole) was added a solution of 2 M methylamine in methanol (100 mL, 200 mmole). The reaction was stirred for 4 h at RT then was concentrated to dryness to afford the crude title compound: 1H NMR (400 Hz, CDCl3) δ 8.55 (d, J=1.4 Hz, 1 H), 8.16 (d, J=7.5 Hz, 1 H), 7.42 (d, J=7.8 Hz, 1 H), 7.15 (t, 1 H), 7.07 (t, 1 H), 3.68 (s, 3 H), 3.41 (s, 3 H), 2.55 (s, 3 H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07557125B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-c719e35e7d5248289ebf3230e4c3671f |
| Source note | uspto-grants-2009_07 |