Hydromorphone Hydrochloride → Hydromorphone

HRID 2259165Notes

Reaction equation

HRID 2259165 reaction equation
[CH3:1][N:2]1[C@@H:19]2[CH2:20][C:7]3=[CH:8][CH:9]=[C:10]([OH:21])[C:11]4[O:12][C@H:13]5[C:14]([CH2:16][CH2:17][C@@H:18]2[C@:5]5([C:6]=43)[CH2:4][CH2:3]1)=[O:15].Cl>O>[CH3:1][N:2]1[C@@H:19]2[CH2:20][C:7]3=[CH:8][CH:9]=[C:10]([OH:21])[C:11]4[O:12][C@H:13]5[C:14]([CH2:16][CH2:17][C@@H:18]2[C@:5]5([C:6]=43)[CH2:4][CH2:3]1)=[O:15]

Participants

3

Reactant 1

HCID 5462347Hydromorphone Hydrochloride

Product 1

HCID 5284570Hydromorphone

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Hydromorphone beads were prepared by dissolving hydromorphone HCl in water, adding Opadry®, and mixing for about 1 hour, and then spraying onto nu pariel 18/20 beads using a Wurster insert. The resultant coated beads were then overcoated with Opadry® Y-5-1442 light pink (15% w/w). The beads were then overcoated with an aqueous dispersion of Aquacoat® to a 15% weight gain according to Table 15 below:

Workup

  1. additionadding Opadry®
  2. additionmixing for about 1 hour

Sources & evidence

ORD record
ord-bbdcccaf987645629f298804ebad8e70
Source dataset
uspto-grants-1995_12
Patent number
US05472712

Reaction notes

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