((2R)-1-methylpyrrolidin-2-yl)methanol → 2(R)-(3-Fluorophenoxymethyl)-1-methylpyrrolidine hydrochloride

Participants

Reaction Steps

Following the procedures of Example 6, substituting (R)-1-methyl-2-pyrrolidinemethanol (Aldrich) for the (S)-1-methyl-2-pyrrolidinemethanol of Example 6, the title compound was prepared. MS: 210 (M+H)+. NMR (CDCl3) δ: 2.20-2.30 (m, 3H), 2.34-2.43 (m, 1H), 3.03 (s, 3H), 3.20-3.30 (m, 1H), 3.72-3.77 (m, 1H), 3.89-3.91 (m, 1H), 4.27 (dd, 1H, J=6, 11.5 Hz), 4.44 (dd, 1H, J=3, 11.5 Hz), 6.82-6.89 (m, 3H), 7.34-7.42 (m, 1H). Anal. Calcd for C12H17ClFNO.0.25 H2O: C, 57.60; H, 7.05; N, 5.59; Found: C, 57.86; H, 6.76; N, 5.59.

Provenance & Evidence