N-Acetyltryptophan → Diphenylmethyl 2-acetamido-3-(3-indolyl)propionate

関与物質

反応手順

Following the method of Example 1, bromodiphenyl methane (5.0 g) and N-acetyl-D,L-tryptophan (5.0 g) gave the title compound which was recrystallised from diethyl ether (2.2 g), m.p. 147°-148° C., 1H NMR (360 MHz, CDCl3) δ7.88 (1H, s), 7.47 (1H, d, J=7 Hz), 7.34-7.28 (15H, m), 6.67 (1H, s), 6.40 (1H, d, J=2 Hz), 5.95 (1H, d, J=7 Hz), 5.14-5.09 (1H, m), 3.40-5.09 (2H, m), 1.91 (3H, s). Found: C, 75.53; H, 6.04; N, 6.88 C26H24N2O3 requires C, 75.71; H, 5.86; N, 6.79%.

情報源と証拠