HCID 19003350, compound → HCID 19003406, compound

Participants

Reaction Steps

8.17 g (19 mmol) of 1,5-di(3'-tert-butyl-5'-methyl-4'-hydroxyphenyl)-1,5-pentanedione in 80 ml of ethyl acetate and 3-5 drops of concentrated sulfuric acid are hydrogenated over 1.6 g of Pd/C (5%) at room temperature under atmospheric pressure. After 12 hours, the uptake of hydrogen has ended. The catalyst is filtered over Celite and the resulting colourless solution is concentrated on a rotary evaporator. Chromatography of the liquid residue (SiO2, hexane/ethyl acetate 19:1) gives 5.13 g (67% of theory) of 1,5-bis(3'-tert-butyl-5'-methyl-4'-hydroxyphenyl)pentane as a viscous oil.

Provenance & Evidence