HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Buspirone Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Buspirone | HCID 2477 | — |
| Solvent | Ethanol | HCID 702 | — |
| Solvent | Isopropanol | HCID 3776 | — |
| Product | Buspirone Hydrochloride | HCID 36431 | — |
Reaction Steps
treating the 8-[4-[4-(pyrimidine-2-yl)-piperazine-1-yl]-butyl]-8-aza-spiro[4.5]decane-7,9-dione base with hydrogen chloride in ethanol or isopropanol under stirring at a temperature between 15° C. and 40° C. and isolating the 8-[4-[4-(pyrimidine-2-yl)-piperazine-1-yl]-butyl]-8-aza-spiro[4.5]decane-7,9-dione hydrochloride melting at 188°-191° C., or
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05473072 |
| Source dataset | uspto-grants-1995_12 |
| ORD ID | ord-d2e9be62b56849299e563af58605657f |
| Source note | uspto-grants-1995_12 |