Triethylamine → 9-Methanesulfonyl-1-nonene
反応式
O[CH:2]([CH2:23]O)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9]N1C(=O)C2N(C)C=NC=2N(C)C1=O.C(O)CCCCCCC=C.[CH3:35][S:36](Cl)(=[O:38])=[O:37].C(N(CC)CC)C>ClCCl.O>[CH3:35][S:36]([CH2:23][CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH:8]=[CH2:9])(=[O:38])=[O:37]参加物
7
反応条件
- 温度
- 0 °C
実験手順
This example illustrates a synthesis procedure for 1-(8,9-dihydroxynonyl)-3,7-dimethylxanthine (CT1561). The synthesis began by adding a solution of 8-nonene-1-ol (1.50 g, 10.5 mmol) in dichloromethane (100 ml) at 0° C. to methanesulfonyl chloride (1.20 g, 813 μl, 10.5 mmol), followed by triethylamine (1.59 g, 15.8 mmol). After stirring for 1 hr at 0° C., the reaction mixture was allowed to warm to room temperature. The reaction mixture was poured into 100 ml of water and extracted with dichloromethane (3×50 ml). The organic portions were combined, dried with sodium sulfate, and evaporated to give 9-methanesulfonyl-1-nonene as a yellow oil (2.25 g, 97% yield, which was used without further purification.
後処理
- temperatureto warm to room temperature
- extractionextracted with dichloromethane (3×50 ml)
- dry with materialdried with sodium sulfate
- customevaporated
出典と根拠
- ORDレコード
- ord-a4ce967a101a4df0ba1bcf424a5d04c1
- 出典データセット
- uspto-grants-1995_12
- 特許番号
- US05473070
反応ノート
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