Diethyl Ether → HCID 178441886, compound

Participants

Reaction Steps

methyl 3-oxo-2-[[2'-(1-triphenylmethyl-1H-tetrazol-5yl)[1,1'-biphenyl]-4-yl]methyl]heptanoate. To a solution of 0.97 g of potassium 1,1-dimethylethylate in 15 ml of dimethylformamide, chilled on an ice bath, under an atmosphere of argon, a solution of 1.3 g of methyl 3-oxoheptanoate in 13 ml of dimethylformamide is added, followed by 1.67 g of lithium bromide and a solution of 5 g of 5-[4-(bromomethyl)[1,1'-biphenyl]-2-yl]-1-triphenylmethyl-1H-tetrazole in 25 ml of dimethylformamide. The reaction mixture is stirred for 5 hours at room temperature and then diluted with 300 ml of ether. The mixture is washed twice with 100 ml of water and then with 100 ml of a saturated aqueous solution of ammonium chloride. It is dried on magnesium sulfate and evaporated in vacuo to obtain 4.6 g of the product in the form of a yellow oil used as such in the following step.

Provenance & Evidence