反应详情

温度

25 °C

To a solution of the nitrile of Step 8 (45 g, 266 mmol) in MeOH (1.36 L) was added H2O(84 mL) and conc. H2SO4 (168 mL). The mixture was heated to reflux for 20 hr, cooled to 25° C., H2O(1 L) was added and the product was extracted with CH2Cl2 (2×1.5 L). The organic extract was washed with H2O and dried over Na2SO4. Concentration of the organic solution gave 36 g (93%) of the title compound.

1. temperatureThe mixture was heated
2. temperatureto reflux for 20 hr
3. extractionthe product was extracted with CH2Cl2 (2×1.5 L)
4. extractionThe organic extract
5. washwas washed with H2O
6. dry with materialdried over Na2SO4