HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,4-dihydro-2H-pyran → 3-(((2-Tetrahydropyranyl)oxy)methyl)benzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,4-dihydro-2H-pyran | HCID 8080 | — |
| Reactant | 3-(Hydroxymethyl)benzaldehyde | HCID 13131455 | — |
| Catalyst | p-Toluenesulfonic acid | HCID 6101 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-(((2-Tetrahydropyranyl)oxy)methyl)benzaldehyde | HCID 19002937 | 87.7% |
Reaction Steps
This alcohol (0.44 mole) was dissolved in CH2Cl2 (500 mL). DHP (50 g, 59 mole) and PTSA (1 g, 5 mmol) were added and the mixture was stirred overnight at r.t. After concentration in vacuo, the residue was purified by flash chromatography (5%→15% EtOAc in toluene) to give 85 g of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05472964 |
| Source dataset | uspto-grants-1995_12 |
| ORD ID | ord-f81e9dea82f4446e8003a161b924e0ff |
| Source note | uspto-grants-1995_12 |