2,3-Dihydroxybutanedioic Acid → HCID 22857730, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of the ester of Step 3 (29.69 g, 59 mmol) in 300 mL of CH2Cl2 at -78° C. was added slowly a solution of diisobutylaluminum hydride 1.5M in toluene (99 mL, 149 mmol) and the mixture was stirred at -78° C. for 30 min. 2M Tartaric acid was then added and the solution was neutralized with 10 N NaOH. The product was extracted in EtOAc, dried over Na2SO4, and concentrated to give 26.90 g, 96%, of the title alcohol.

Provenance & Evidence