HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetyl chloride → N-(2-chloropyridin-3-yl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | 2-Chloro-3-pyridylamine | HCID 80528 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N-(2-chloropyridin-3-yl)acetamide | HCID 4338791 | 105.2% |
Reaction Steps
To a solution of 2-chloro-3-pyridinamine (14.9 g, 116 mmol) in 300 mL of THF was added K2CO3 (32 g, 232 mmol) and acetyl chloride (12 mL, 169 mmol) and the mixture was stirred at room temperature overnight. Saturated NH4Cl was added and the product was extracted in EtOAc, dried over Na2SO4, and filtered through silica to yield 20.81 g of the title amide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05472964 |
| Source dataset | uspto-grants-1995_12 |
| ORD ID | ord-58566421fd714bcbad34d4c21fc54a0a |
| Source note | uspto-grants-1995_12 |