HCID 68831647, compound → HCID 11315803, compound

HRID 225954Notes

Reaction equation

HRID 225954 reaction equation
C([O:5][C:6](=[O:33])[CH2:7][C@H:8]([NH:12][C:13]([C@@:15]1([CH:30]([CH3:32])[CH3:31])[O:19][N:18]=[C:17]([C:20]2[C:29]3[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=3)[CH:23]=[CH:22][N:21]=2)[CH2:16]1)=[O:14])[C:9]([OH:11])=O)(C)(C)C.[CH:34]([Mg]Br)=[CH2:35]>>[CH:30]([C@:15]1([C:13]([NH:12][C@H:8]([C:9](=[O:11])[CH:34]=[CH2:35])[CH2:7][C:6]([OH:5])=[O:33])=[O:14])[O:19][N:18]=[C:17]([C:20]2[C:29]3[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=3)[CH:23]=[CH:22][N:21]=2)[CH2:16]1)([CH3:31])[CH3:32]

Participants

3

Reactant 2

HCID 68831647HCID 68831647, compoundHCID 178418507HCID 178418507, compound

Product 1

HCID 11315803HCID 11315803, compound

Procedure

Weinreb amide derivative of (2S)-4-(tert-butoxy)-2-({[(5R)-5-isopropyl-3-(1-isoquinolinyl)-4,5-dihydro-5-isoxazolyl]carbonyl}amino)-4-oxobutanoic acid (condensed derivative with N,O-dimethylhydroxylamine) and vinyl magnesium bromide were reacted, and the resulting compound was reacted according to the same procedure as Example 2 to give the title compound.

Workup

  1. customthe resulting compound was reacted

Sources & evidence

ORD record
ord-9614183280bd4940b1805259a0fc8084
Source dataset
uspto-grants-2009_07
Patent number
US07557133B2

Reaction notes

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