Acrylonitrile → HCID 22131890, compound

HRID 2259549Notes

Reaction equation

HRID 2259549 reaction equation
[C:1]([CH2:4][N:5]1[CH2:16][CH2:15][NH:14][CH2:13][CH2:12][N:11]([CH2:17][C:18]([OH:20])=[O:19])[CH2:10][CH2:9][N:8]([CH2:21][C:22]([OH:24])=[O:23])[CH2:7][CH2:6]1)([OH:3])=[O:2].[OH-].[Na+].[C:27](#[N:30])[CH:28]=[CH2:29]>O>[C:1]([CH2:4][N:5]1[CH2:16][CH2:15][N:14]([CH2:29][CH2:28][C:27]#[N:30])[CH2:13][CH2:12][N:11]([CH2:17][C:18]([OH:20])=[O:19])[CH2:10][CH2:9][N:8]([CH2:21][C:22]([OH:24])=[O:23])[CH2:7][CH2:6]1)([OH:3])=[O:2]

Participants

5

Reactant 3

HCID 7855AcrylonitrileHCID 14798Sodium HydroxideHCID 1078301,4,7-Tris(carboxymethyl)-1,4,7,10-tetraazacyclododecane

Product 1

HCID 22131890HCID 22131890, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Into a 50 ml round bottom flask was placed 5.22 g (0.0151 mol) of 1,4,7,-triscarboxymethyl-1,4,7,10-tetraazacyclododecane (DO3A) and dissolved in 21 ml of water. The pH of the solution was raised to 8.28 with 6N NaOH. Then 1.35 ml (1.09 g, 0.0205 mol) of acrylonitrile was added and the reaction allowed to stir overnight at room temperature. The reaction is then concentrate in vacuo, and then re-dissolved in methanol and concentrated in vacuo.

Workup

  1. customInto a 50 ml round bottom flask was placed
  2. concentrationThe reaction is then concentrate in vacuo
  3. dissolutionre-dissolved in methanol
  4. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-583ee8a28cd44cb7b78eaff42d47353a
Source dataset
uspto-grants-1995_12
Patent number
US05474756

Reaction notes

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