HCID 10692325, compound → HCID 10621099, compound

Participants

Reaction Steps

A mixture of tert-butyl (2S,4R)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-[(1E)-3-ethoxy-3-oxoprop-1-en-1-yl]pyrrolidine-1-carboxylate (35 g, 0.087 mmol)) and Pd/C (3.5 g) in ethyl acetate (400 ml) was hydrogenated under a pressure of 80 psi for 2 h. The reaction mixture was filtered off and filtrate concentrated under vacuum to give tert-butyl (2R,4R)-4-{[tert-butyl(dimethyl)silyl]oxy}-2-(3-ethoxy-3-oxopropyl)pyrrolidine-1-carboxylate (28 g) as a liquid. Yield: 80%

Provenance & Evidence