Chloroacetyl chloride → HCID 19001471, compound

HRID 2259591Notes

Reaction equation

[NH2:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][C:11]=1[Cl:12])[N:8]=[CH:7][N:6]=[C:5]2[NH:13][C:14]1[CH:19]=[CH:18][C:17]([Cl:20])=[C:16]([Cl:21])[CH:15]=1.[Cl:22][CH2:23][C:24](Cl)=[O:25]>>[ClH:12].[Cl:12][C:11]1[CH:10]=[C:9]2[C:4]([C:5]([NH:13][C:14]3[CH:19]=[CH:18][C:17]([Cl:20])=[C:16]([Cl:21])[CH:15]=3)=[N:6][CH:7]=[N:8]2)=[CH:3][C:2]=1[NH:1][C:24](=[O:25])[CH2:23][Cl:22]

Participants

Reactant 2

HCID 6577Chloroacetyl chloride

HCID 19001482HCID 19001482, compound

Product 1

HCID 19001471HCID 19001471, compoundYield 76%

Procedure

Using an analogous procedure to that described in Example 4, 6-amino-7-chloro-4-(3',4'-dichloroanilino)quinazoline was reacted with 2-chloroacetyl chloride to give 7-chloro-6-(2-chloroacetamido)-4-(3',4'-dichloroanilino)quinazoline hydrochloride in 76% yield, m.p.>280° C.;

Sources & evidence

ORD record: ord-b0894c8d140e486087e48ce18511e288
Source dataset: uspto-grants-1995_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05475001

Reaction notes

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