Chloroacetyl chloride → HCID 19001455, compound

HRID 2259592Notes

Reaction equation

[F:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]([NH:12][C:13]3[CH:18]=[CH:17][CH:16]=[C:15]([CH3:19])[CH:14]=3)=[N:7][CH:8]=[N:9]2)=[CH:4][C:3]=1[NH:20][CH3:21].[Cl:22][CH2:23][C:24](Cl)=[O:25]>>[ClH:22].[Cl:22][CH2:23][C:24]([N:20]([C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:2]=1[F:1])[N:9]=[CH:8][N:7]=[C:6]2[NH:12][C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([CH3:19])[CH:14]=1)[CH3:21])=[O:25]

Participants

Reactant 2

HCID 6577Chloroacetyl chloride

HCID 19001475HCID 19001475, compound

Product 1

HCID 19001455HCID 19001455, compound

Procedure

Using an analogous procedure to that described in Example 4, 7-fluoro-6-methylamino-4-(3'-methylanilino)quinazoline was reacted with 2-chloroacetyl chloride to give 6-(2-chloro-N-methylacetamido)-7-fluoro-4-(3'-methylanilino)quinazoline hydrochloride (0.097 g);

Sources & evidence

ORD record: ord-6632e3e345744ba5b0835b45032d984e
Source dataset: uspto-grants-1995_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05475001

Reaction notes

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